Tankwa Karoo is located a 4 to 5 hour drive on the border between the Northern Cape and the Western Cape. t

The Tankwa Karoo National Park can be accessed from Calvinia, Sutherland, Ceres or Middlepos with entrance gates on the southern and northern boundaries. The park lies about 70 km due west of Sutherland near the border of the Northern Cape and Western Cape, in one of the most arid regions of South Africa.

It is bounded on the east by the Roggeveld Mountains, on the west by the Cederberg, to the north by the Kouebokkeveld Mountains and on the south by the scattered foothills of the Koedoesberge and Klein Roggeveld Mountains, and the Tankwa River.

Distances from the nearest towns are: Ceres (180 km), Sutherland (120 km), Calvinia (110 km) and Middelpos (52 km).